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Question #578

What procedure will allow me to obtain an INR estimate in the comfort of my home that agrees to within 0.3 with the INR measurement from Quest Diagnostics, using just an Alere Hemosense kit and simple algebra or graphing?

The accuracy of the Alere measurements has recently been questioned (e.g., http://news.alere.com/~/media/Files/A/Alere-New...). I seek a procedure that will allow me to use a few initial weekly measurements to obtain corrected INR estimates sufficiently close to those from Quest Diagnostics to maintain my INR within its recommended range without needing to visit Quest Diagnostics.

I can provide twelve measurements as data for the procedure. Each week for six weeks, I can take an INR measurement using the Alere kit within half an hour of a standard weekly INR measurement at Quest Diagnostics. (I can, for example, take my Alere kit with me to Quest Diagnostics, and use it right after each weekly blood drawing is completed.)

Using the first five pairs of measurements and the sixth single measurement using the Alere kit, I want to predict the sixth measurement from Quest Diagnostics. The procedure must provide an explicit, numerical prediction for the sixth measurement from Quest Diagnostics. The procedure will be considered correct if the predicted value agrees to within 0.3 with the sixth INR measurement performed at Quest Diagnostics. The procedure will be considered incorrect if the predicted value does not agree to within 0.3 with the sixth INR measurement performed at Quest Diagnostics.

I am comfortable with basic 9th grade algebra.

Evidence supporting my Final Answer will include results from the six Alere kit measurements and the electronic scans of the six Quest Diagnostic measurements. Submitted measurements will include their registered times and dates. Personally identifiable information may be redacted from the scanned reports from Quest Diagnostics.



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